Impact of COVID-19 on brain health and cognitive function in older adults

Brain signature of SARS-CoV-2 Infection and its impact on long-term cognitive functioning in older adults

NIH-funded research University of Rochester · NIH-10884447

This study is looking at how COVID-19 might impact the brain and thinking skills in older adults, helping us understand any long-term effects it could have on memory and mental health.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Rochester NIH-funded
Lab location1 site (Rochester, United States)
Project IDNIH-10884447 on NIH RePORTER

What this research studies

This research investigates how SARS-CoV-2 infection affects the brain and cognitive functioning in older adults. It examines the potential long-term consequences of COVID-19 on cognitive health, particularly focusing on the mechanisms that may lead to cognitive impairment and dementia. The study utilizes a combination of clinical assessments and advanced imaging techniques to understand the relationship between COVID-19 and changes in brain structure and function. By identifying these effects, the research aims to provide insights into the management and treatment of cognitive decline in this population.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults who have had a confirmed SARS-CoV-2 infection and are experiencing cognitive difficulties.

Not a fit: Patients who have not been infected with SARS-CoV-2 or those without cognitive impairment may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved understanding and management strategies for cognitive impairment in older adults who have recovered from COVID-19.

How similar studies have performed: Other research has indicated potential cognitive impacts of viral infections, suggesting that this area of investigation is both relevant and timely.

Where this research is happening

Rochester, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer disease dementiaAlzheimer syndromeAlzheimer's Disease
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.