Impact of binge drinking and high-fat diets on brain health
Effects of binge ethanol on neuroinflammation and neurodegeneration with high fat diets
['FUNDING_R21'] · SETON HALL UNIVERSITY · NIH-10668068
This study is looking at how binge drinking and eating a lot of fatty foods might harm the brains of older adults, especially in relation to diseases like Alzheimer's, and it hopes to find ways to protect the brain using omega-3 fatty acids.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SETON HALL UNIVERSITY (nih funded) |
| Locations | 1 site (SOUTH ORANGE, UNITED STATES) |
| Trial ID | NIH-10668068 on ClinicalTrials.gov |
What this research studies
This research investigates how binge drinking and high-fat diets contribute to inflammation and degeneration in the brain, particularly in older adults. It aims to understand the connection between alcohol consumption, obesity, and neurodegenerative diseases like Alzheimer's. The study utilizes animal models to explore the effects of binge ethanol on neuroinflammation and the potential protective role of omega-3 fatty acids. By analyzing biological pathways, the research seeks to identify mechanisms that could lead to better interventions for cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who engage in binge drinking and have high-fat diet habits.
Not a fit: Patients who do not consume alcohol or have a healthy diet may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neurodegenerative diseases in individuals affected by binge drinking and obesity.
How similar studies have performed: Previous research has shown that dietary interventions, particularly with omega-3 fatty acids, can have beneficial effects on brain health, suggesting a promising avenue for this study.
Where this research is happening
SOUTH ORANGE, UNITED STATES
- SETON HALL UNIVERSITY — SOUTH ORANGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHANG, SULIE L. — SETON HALL UNIVERSITY
- Study coordinator: CHANG, SULIE L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.