Immunoglobulin replacement after CD19 CAR‑T therapy
Immunoglobulin Replacement Therapy and Infectious Complications After CD19-Targeted CAR-T-Cell Therapy
This randomized trial compares antibody replacement shots (IgG) versus placebo for adults who received CD19 CAR‑T therapy to reduce infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11167455 on NIH RePORTER |
What this research studies
If you join, you'll be randomly assigned to receive periodic immunoglobulin G (IgG) replacement or a placebo and followed over time. The team will track infections, measure antibodies against common germs, and monitor CAR‑T cell levels and function. They will also record side effects, hospital visits, and healthcare use related to infections. The goal is to determine whether routine IgG replacement lowers infection risk without harming CAR‑T treatment effects.
Who could benefit from this research
Good fit: Adults who have received CD19-targeted CAR‑T cell therapy and are being followed for immune recovery or infection prevention are the ideal candidates.
Not a fit: People who have not had CD19 CAR‑T therapy, children, or those with uncontrolled active infections are unlikely to benefit from this trial.
Why it matters
Potential benefit: If successful, it could show who truly needs IgG replacement after CAR‑T and help reduce serious infections in that group.
How similar studies have performed: Observational studies suggest many patients retain pathogen-specific antibodies after CAR‑T, but no randomized trials have proven routine IgG replacement prevents infections.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Hill, Joshua Aiden — Fred Hutchinson Cancer Center
- Study coordinator: Hill, Joshua Aiden
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.