Immune strategies to shrink the HIV reservoir
Multi-OMICS identification and validation of mechanisms triggered by Immune interventions aimed at reducing the size of the replication competent Reservoir
Testing immune-based approaches to shrink the hidden HIV reservoir in people living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11412547 on NIH RePORTER |
What this research studies
This program brings together clinics and labs to study how immune treatments affect the replication-capable HIV that can hide in the body. Researchers will use multi-omics (genes, proteins, cells) plus machine learning to look for biological signals linked to reductions in the reservoir, and some projects include immune interventions delivered at clinical sites. The Administrative Core coordinates the teams, handles ethics and finances, and makes sure the research follows high standards. If you live with HIV, this work aims to identify immune approaches that might lower the amount of virus able to restart infection.
Who could benefit from this research
Good fit: Ideal candidates are adults living with HIV who are on stable antiretroviral therapy and willing to attend clinic visits and provide blood or tissue samples for research.
Not a fit: People without HIV, children if the projects are limited to adults, or those medically unable to receive immune interventions or provide required samples may not receive direct benefit from participation.
Why it matters
Potential benefit: If successful, the work could lead to therapies that reduce the hidden, replication-competent HIV reservoir and move people closer to long-term remission without continuous therapy.
How similar studies have performed: Previous immune-based and reservoir-targeting approaches have shown limited but sometimes promising signals in small studies, so this integrated multi-omics and intervention program builds on existing work but tests new combined strategies.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Sekaly, Rafick Pierre — Emory University
- Study coordinator: Sekaly, Rafick Pierre
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.