Immune responses to vaccines in children with sickle cell disease
Immune signatures of vaccine responses in children with sickle cell disease
This project looks at how vaccines trigger immune responses in children with sickle cell disease to find why some children make weaker protection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11228781 on NIH RePORTER |
What this research studies
If my child has sickle cell disease, the team will take blood before and after routine vaccinations to study immune cells, antibodies, and long-term immune memory using advanced single-cell, transcriptomic, and proteomic methods. They will examine both innate immune activity and adaptive responses to identify molecular patterns linked to poorer vaccine protection. The researchers will combine these datasets with computational systems-biology tools to create a detailed map of immune differences in children with sickle cell disease. The effort aims to build a resource that could guide better vaccine strategies or supportive treatments for kids like mine.
Who could benefit from this research
Good fit: Children with sickle cell disease who are receiving routine vaccinations and can provide blood samples and relevant medical history.
Not a fit: People without sickle cell disease or those unable to attend clinic visits or provide blood samples would not directly benefit from participation.
Why it matters
Potential benefit: Could lead to ways to improve vaccine protection and reduce infection risk for children with sickle cell disease.
How similar studies have performed: Previous work has shown reduced vaccine responses in sickle cell disease, but using single-cell, transcriptomic, and proteomic systems approaches to define underlying signatures is relatively new.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Yildirim, Inci Burcin — Yale University
- Study coordinator: Yildirim, Inci Burcin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.