Immune responses and treatment of HIV-associated Kaposi sarcoma
Project 2
This project looks at how the immune system and current treatments affect Kaposi sarcoma in people living with HIV, especially in sub-Saharan Africa.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11415853 on NIH RePORTER |
What this research studies
If you have HIV and Kaposi sarcoma, researchers will use standard staging rules to classify disease and follow patients over time while they receive antiretroviral therapy with or without chemotherapy. They will take blood tests such as CD4 counts and T cell measurements and monitor tumor changes and other illnesses. The team will compare who improves, who stays the same, and who worsens to find immune patterns linked to outcomes. The goal is to learn when ART alone is enough and when additional cancer treatment is needed.
Who could benefit from this research
Good fit: People living with HIV who are diagnosed with Kaposi sarcoma, particularly those receiving care in sub-Saharan Africa or at participating clinics, would be ideal candidates.
Not a fit: People without Kaposi sarcoma or without HIV, and those whose care is outside participating clinics, would not benefit directly from this project.
Why it matters
Potential benefit: Could help doctors choose the right treatment (ART alone versus adding chemotherapy) and improve outcomes for people with HIV-associated Kaposi sarcoma.
How similar studies have performed: Previous work shows that restoring immunity with ART often shrinks Kaposi sarcoma in many patients, but responses are inconsistent and predicting who will benefit remains limited.
Where this research is happening
New Orleans, United States
- Lsu Health Sciences Center — New Orleans, United States (Active)
Researchers
- Principal investigator: West, John T. — Lsu Health Sciences Center
- Study coordinator: West, John T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.