Immune markers that predict who will get severe acute pancreatitis
Official title: Immune Signatures and Clinical Outcomes in Acute Pancreatitis
Funded at Ohio State University · NIH-11333744 · Data updated 2026-11-12
Researchers will measure immune system proteins in people admitted with acute pancreatitis to spot early signs of who may become severely ill.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 4, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $674,554 |
| NIH project number | 5R01DK134698-04 |
| Project ID | NIH-11333744 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults recently admitted to the hospital with acute pancreatitis who can provide blood samples and clinical follow-up information.
✕Less likely to help
People without acute pancreatitis or those fully recovered before enrollment would not directly benefit from this study.
What this research studies
You would be followed after hospital admission for acute pancreatitis while researchers collect blood samples and clinical information at multiple hospitals. Lab tests will measure a panel of immune proteins (including angiopoietin-2, hepatocyte growth factor, interleukin-8, resistin, and TNF receptor-1) and researchers will use bioinformatics to find patterns linked to severe disease. The study is a prospective multi-center observational cohort designed to validate an early blood-marker panel and to explore immune pathways driving organ failure. Results could help doctors identify high-risk patients earlier and point to new treatment targets.
Why it matters
Potential benefit: If successful, this work could help doctors identify patients at high risk for severe pancreatitis earlier so they can receive closer monitoring or be offered targeted trials.
How similar studies have gone: Pilot work by the team found a multi-cytokine blood panel that predicted severe pancreatitis with high accuracy, but it needs multi-center validation.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Papachristou, Georgios I — Ohio State University
- Study coordinator: Papachristou, Georgios I
Related research
Other NIH-funded projects on the same topics.
-
Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
-
Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
-
Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
-
Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
-
Type 1 Diabetes in Acute Pancreatitis in Diabetes Patients at Stanford
A Stanford-led project helps people with brittle type 1 diabetes who also experience pancreatitis by following them in a long-term study to understand how acute pancreatitis affects diabetes.
-
Epidemiology and causes of diabetes after acute pancreatitis
A long-term study following people who have had acute pancreatitis to understand how often diabetes develops, why it happens, and how it progresses.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.