Immune data hub focused on preventing CMV transmission
Immune Data Science Core (IDS Core)
This project uses advanced data analysis to understand how vaccines and antibodies can help stop CMV passing from mothers to babies.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11169054 on NIH RePORTER |
What this research studies
Researchers will combine and analyze detailed immune data from several projects and laboratory model systems to learn what controls CMV transmission. They will work with many types of measurements, including antibody levels and function, cytokines, single-cell RNA and immune receptor sequencing, and spatial protein and RNA maps. The main outcomes include whether CMV is detectable by PCR, maternal viral load over time, and viral shedding in urine and saliva, with experiments done across different viral strains, animal immune states, and treatments such as vaccines or hyperimmune globulin. The goal is to find immune markers and computational models that explain and predict when transmission is blocked and which vaccine or antibody approaches look most promising.
Who could benefit from this research
Good fit: People most relevant would be pregnant women with CMV infection or those at high risk of CMV who can provide clinical samples or participate in related clinical studies.
Not a fit: People without CMV exposure or with unrelated health conditions are unlikely to receive direct personal benefit from this core's work.
Why it matters
Potential benefit: If successful, this work could identify immune markers and strategies that help prevent mother-to-child CMV transmission and guide better vaccines or antibody therapies.
How similar studies have performed: Previous animal and human studies have suggested roles for antibodies and vaccines in reducing CMV risk but have not yet produced a consistently effective preventive solution, so this work builds on mixed but promising prior results.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Chan, Cliburn C — Weill Medical Coll of Cornell Univ
- Study coordinator: Chan, Cliburn C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.