Immune cells in the brain's choroid plexus and aging
The development and function of aging-associate innate lymphoid cells in the choroid plexus
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11457049
This project tests whether boosting a specific type of immune cell in the brain's choroid plexus can reduce inflammation and help people with Alzheimer's-related memory problems, using mouse experiments and human tissue samples.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11457049 on ClinicalTrials.gov |
What this research studies
This work focuses on group 2 innate lymphoid cells (ILC2) that build up in the choroid plexus as people age. Researchers will use special mouse models to trace where these cells come from and will move or remove them to see how they affect the aging brain. They will compare mouse results to human tissue observations to confirm relevance to people. Finally, they will test whether enhancing ILC2 function can lower brain inflammation and improve memory in mouse models that have Alzheimer’s-related pathology.
Who could benefit from this research
Good fit: Ideal candidates would be older adults with Alzheimer’s disease or age-related cognitive decline who can provide tissue samples or consider joining future clinical trials.
Not a fit: People with non‑Alzheimer causes of cognitive impairment, much younger individuals, or those unable or unwilling to provide samples or join trials are less likely to benefit directly.
Why it matters
Potential benefit: If successful, this work could point to new immune-based treatments that reduce brain inflammation and improve memory for people with Alzheimer's disease.
How similar studies have performed: Immune-targeting approaches have shown benefit in animal models of neuroinflammation, but targeting ILC2 cells specifically for Alzheimer's is a relatively new and largely untested idea.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, QI — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: YANG, QI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease pathology, Alzheimer's disease patient