Immune-based treatments for aggressive Group 3 medulloblastoma
Enabling immunotherapy for high-risk Group 3 medulloblastoma via systems immunology
Working to unlock the immune system to create new treatments for children with high-risk Group 3 medulloblastoma.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11162311 on NIH RePORTER |
What this research studies
This project maps the immune cells and their neighborhoods inside aggressive Group 3 medulloblastoma to learn how the tumor hides from the immune system. Researchers will use single-cell and spatial multi-omics to profile individual cells and tumor environments and perform CRISPR-based screens in immunocompetent mouse models that mimic the human tumor. The team aims to find immune-suppressing interactions and specific targets that could be turned into immune therapies for children. The overall goal is to generate treatment leads that can move toward clinical testing for high-risk pediatric patients.
Who could benefit from this research
Good fit: Children with high-risk Group 3 medulloblastoma, especially tumors with MYC overexpression or those with recurrent or treatment-refractory disease, would be the primary candidates for eventual therapies from this work.
Not a fit: Children with other medulloblastoma subgroups or unrelated cancers are unlikely to receive direct benefit from this specific project.
Why it matters
Potential benefit: Could lead to new immune-based therapies that improve survival and reduce harmful long-term effects for children with high-risk Group 3 medulloblastoma.
How similar studies have performed: Single-cell and spatial immune profiling have revealed actionable targets in other cancers, but applying an integrated systems immunology and CRISPR screening approach to Group 3 medulloblastoma is largely novel.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Chi, Hongbo — St. Jude Children's Research Hospital
- Study coordinator: Chi, Hongbo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.