Immune and genetic markers of MIS-C
Immunologic and Predictive Features of MIS-C
This project will look for immune system and genetic signs in children who develop MIS-C after COVID-19 to help predict and diagnose the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11163212 on NIH RePORTER |
What this research studies
You would be asked to share clinical information and blood samples while your child is sick with MIS-C and again during recovery, and researchers will compare these to children who had COVID-19 but did not get MIS-C. Laboratory teams will map immune responses, antibodies, and genetic differences with advanced tests. Computer algorithms will search the combined clinical and lab data for patterns that might predict who is at risk, help make diagnosis earlier, and suggest likely outcomes. The goal is to turn those patterns into practical markers clinicians can use for care.
Who could benefit from this research
Good fit: Ideal candidates are children with recent SARS-CoV-2 infection who have suspected or confirmed MIS-C and are seen at pediatric hospitals.
Not a fit: Adults without MIS-C, people with unrelated health problems, or children with no history of recent COVID-19 are unlikely to receive direct benefit.
Why it matters
Potential benefit: Could lead to tests that identify children at higher risk for MIS-C, enable earlier diagnosis, and guide treatment choices.
How similar studies have performed: Other research has found immune and antibody differences in MIS-C patients, but dependable predictive tests have not yet been established.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Bogunovic, Dusan — Columbia University Health Sciences
- Study coordinator: Bogunovic, Dusan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.