Imaging zinc release in the brain during sound processing
Official title: Fluorescent Indicators for Imaging Synaptic Zinc in Cortical Sound Processing
Funded at University of Virginia · NIH-10888267 · Data updated 2026-11-12
This study is exploring new ways to see how zinc ions are released in the brain when we hear sounds, using special mouse models to help us understand how zinc affects our ability to process sounds, which could lead to better treatments for hearing-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 30, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $655,437 |
| NIH project number | 5R01EB033172-03 |
| Project ID | NIH-10888267 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with auditory processing disorders or neurodegenerative conditions affecting sound perception.
✕Less likely to help
Patients with conditions unrelated to auditory processing or zinc dysregulation may not receive any benefit from this research.
What this research studies
This research focuses on developing advanced fluorescent indicators to visualize the release of zinc ions in the brain, particularly in response to sound stimuli. By creating genetically encoded zinc indicators, the researchers aim to overcome current limitations in imaging techniques that have hindered the study of zinc's role in auditory processing. The project involves innovative mouse models that allow for targeted gene expression and knockout, enabling a deeper understanding of how zinc dynamics affect sound processing in the auditory cortex. Patients may benefit from insights gained into the mechanisms of auditory processing and potential treatments for related conditions.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of auditory processing and lead to new therapeutic strategies for auditory-related disorders.
How similar studies have gone: While the use of genetically encoded indicators is established, the specific application of imaging synaptic zinc dynamics in live animals during auditory processing is a novel approach.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Ai, Huiwang — University of Virginia
- Study coordinator: Ai, Huiwang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.