Imaging the inner ear to understand hearing loss
OCT imaging of the human inner ear
This study is looking at how the fluid in the inner ear works in people with sudden hearing loss, like those with Meniere’s disease, by using a special imaging technique, and it’s for adults who are having ear surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11022216 on NIH RePORTER |
What this research studies
This research investigates the use of optical coherence tomography (OCT) to visualize the fluid compartments of the human inner ear, which may help explain sudden hearing loss in adults. By comparing the endolymph-to-perilymph ratio in healthy individuals and those with conditions like Meniere’s disease, the study aims to uncover the underlying mechanisms of these disorders. Participants undergoing mastoid surgery will be involved, allowing researchers to gather data on how fluid levels differ in various ear conditions. This innovative approach could lead to better understanding and treatment of hearing loss.
Who could benefit from this research
Good fit: Ideal candidates include adults with sudden sensorineural hearing loss or those diagnosed with Meniere’s disease or vestibular schwannoma.
Not a fit: Patients with hearing loss due to non-inner ear related causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients experiencing sudden hearing loss.
How similar studies have performed: While the use of OCT in this context is relatively novel, similar imaging techniques have shown promise in other areas of medical research.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Oghalai, John S — University of Southern California
- Study coordinator: Oghalai, John S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.