Imaging the human retina to understand aging and eye diseases
Official title: In vivo Imaging of the Human Retina at the Molecular Level
Funded at Doheny Eye Institute · NIH-11041079 · Data updated 2026-11-12
This study is looking at how advanced imaging can help us see the health of the retina in people with age-related macular degeneration (AMD), which could lead to better treatments for this eye condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Doheny Eye Institute NIH-funded |
| Lab location | 1 site (Pasadena, UNITED STATES) |
| Project start | March 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $514,294 |
| NIH project number | 5R01EY032994-02 |
| Project ID | NIH-11041079 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing symptoms of age-related macular degeneration or those at risk due to age or genetic factors.
✕Less likely to help
Patients with retinal conditions unrelated to aging or those who do not have access to the imaging technology may not benefit from this research.
What this research studies
This research focuses on using advanced imaging techniques to observe the human retina at a molecular level, particularly in relation to age-related macular degeneration (AMD). By employing fluorescence lifetime imaging ophthalmoscopy (FLIO) combined with adaptive optics, the study aims to measure the metabolic status and oxidative stress in retinal cells. This innovative approach will allow for detailed analysis of the retina's health and could lead to better understanding and treatment of age-related eye conditions. Patients may benefit from insights gained through this imaging technology, which could inform future therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments for age-related macular degeneration and other retinal diseases.
How similar studies have gone: Previous research using similar imaging techniques has shown promise in understanding retinal diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Doheny Eye Institute
Pasadena, United States Active
Researchers
- Principal investigator: Sadda, Srinivas R — Doheny Eye Institute
- Study coordinator: Sadda, Srinivas R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.