Imaging the body's immune response during cancer treatment
[18F]4FN PET Imaging of Innate Immunity Activation During Immunotherapy-Induced Adverse Events
This study is looking at how your immune system responds during cancer treatments like CAR T-cell therapy, using a special imaging technique to spot any early signs of inflammation, so we can help manage your care better and improve your treatment experience.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10918135 on NIH RePORTER |
What this research studies
This research investigates how the body's innate immune system reacts during immunotherapy for cancer, particularly focusing on adverse events that can occur as a result of treatment. Using a novel imaging technique called [18F]4FN PET, researchers aim to visualize and quantify the activation of immune responses in patients undergoing therapies like CAR T-cell treatment. By identifying inflammatory responses early, the goal is to improve patient management and outcomes during cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients undergoing immunotherapy, particularly those at risk of experiencing immune-related adverse events.
Not a fit: Patients who are not receiving immunotherapy or those with conditions unrelated to immune system activation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and management of immune-related side effects in cancer patients receiving immunotherapy.
How similar studies have performed: Previous research has shown promise in using imaging techniques to monitor immune responses, suggesting that this approach could be effective.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Piwnica-Worms, David — University of Tx Md Anderson Can Ctr
- Study coordinator: Piwnica-Worms, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.