Imaging reactive oxygen species in heart injury after blood flow restoration
Official title: Non-invasive imaging of reactive oxygen species in reperfusion injury myocardial infarction
Funded at University of Pennsylvania · NIH-11080947 · Data updated 2026-11-12
This study is looking at how restoring blood flow to the heart after a heart attack can sometimes cause more damage, and it aims to find ways to protect the heart during treatment, which could help patients like you recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $670,086 |
| NIH project number | 5R01HL169378-03 |
| Project ID | NIH-11080947 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have experienced a myocardial infarction and are undergoing treatment that involves restoring blood flow to the heart.
✕Less likely to help
Patients who have not experienced a heart attack or those with chronic heart conditions unrelated to acute myocardial infarction may not benefit from this research.
What this research studies
This research investigates how the restoration of blood flow to the heart after a heart attack can lead to additional injury, known as reperfusion injury. It aims to understand the role of reactive oxygen species and iron in this process using advanced imaging techniques like magnetic resonance imaging and positron emission tomography. By studying these mechanisms in a large animal model, the research seeks to improve clinical care for patients suffering from myocardial infarction. The findings could help identify new therapeutic targets to mitigate heart damage during treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that minimize heart damage during and after a heart attack.
How similar studies have gone: Previous research has shown promise in using imaging techniques to study heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Witschey, Walter R.t. — University of Pennsylvania
- Study coordinator: Witschey, Walter R.t.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.