Imaging neuroinflammation in Alzheimer's disease
Quantitative Endogenous MRI Imaging of Neuroinflammation in AD
This study is testing a new way to take pictures of the brain to see how inflammation affects people with Alzheimer's disease, helping us understand the condition better and find important clues about how it progresses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11017736 on NIH RePORTER |
What this research studies
This research focuses on developing a new imaging technique called Diffusion Dictionary Imaging (DDI) to visualize and quantify neuroinflammation in the brains of individuals with Alzheimer's disease. By using advanced diffusion MRI technology, the study aims to track the movement of water molecules in the brain, which can reveal changes associated with neuroinflammation. This approach seeks to improve the understanding of Alzheimer's pathology and potentially identify key factors involved in the disease's progression. The research will also utilize previously collected MRI data to enhance the analysis and findings.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with other forms of dementia or neurological disorders unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools for Alzheimer's disease, allowing for earlier detection and more targeted treatments.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques for studying neuroinflammation, but this specific approach with DDI is novel.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Wang, Qing — Washington University
- Study coordinator: Wang, Qing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.