Imaging lung function in children while they breathe normally
Dynamic imaging of lung function in free-breathing subjects
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10981859
This study is testing a new way to take pictures of how well lungs are working in kids and others who can't hold their breath, using a special gas that makes it easier for them to breathe normally while we check their lung function.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10981859 on ClinicalTrials.gov |
What this research studies
This research aims to develop a new imaging technique using hyperpolarized 129Xe MRI to assess lung function in children and other patients who cannot hold their breath. By allowing imaging during free breathing, the study will provide more accurate information about how well the lungs are working in real-time. The method involves a small tube connected to a facemask that delivers a specific amount of gas with each breath, making it easier for patients to participate without needing special training. This approach is particularly beneficial for young children and those with severe lung conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include children aged 0-11 years and individuals with conditions that impair their ability to hold their breath.
Not a fit: Patients who are older than 11 years or those without lung function issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and management of lung diseases in children and other patients.
How similar studies have performed: Previous research using hyperpolarized gas MRI has shown promise, but this specific approach of free-breathing imaging is novel.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIZI, RAHIM R — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: RIZI, RAHIM R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.