Imaging kidney cell function in diabetes using a special tracer
Renal Molecular Imaging of Mesangial Cell Function with Tc-99m-Tilmanocept
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10666353
This study is looking at a special imaging tool to help find early signs of kidney problems in people with diabetes, so we can catch issues sooner and help keep their kidneys healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10666353 on ClinicalTrials.gov |
What this research studies
This research investigates the use of Tc-99m-tilmanocept, a molecular imaging agent, to assess mesangial cell function in patients with diabetic nephropathy. The study aims to identify early changes in kidney function that are not detected by current standard methods, which typically focus on later-stage indicators like albuminuria and serum creatinine levels. By using advanced imaging techniques, the research seeks to provide a more sensitive biomarker for early detection of kidney issues in diabetic patients. This could lead to improved monitoring and earlier intervention for those at risk of chronic kidney disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are at risk of developing diabetic nephropathy.
Not a fit: Patients without diabetes or those who do not have any signs of kidney dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enable earlier diagnosis and treatment of diabetic nephropathy, potentially preventing progression to chronic kidney disease.
How similar studies have performed: While the approach of using molecular imaging for kidney function is innovative, similar imaging techniques have shown promise in other areas of kidney disease research.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOH, CARL K — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: HOH, CARL K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.