Imaging CD4 cells in patients with HIV
Non-Invasive In Vivo Imaging of CD4 pool in HIV-1 Infected Patients
This study is testing a new way to take pictures of immune cells in people with HIV, helping doctors understand how the virus affects these cells and how they bounce back after treatment, so they can better manage care for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Leidos Biomedical Research, INC. NIH-funded |
| Lab location | 1 site (Frederick, United States) |
| Project ID | NIH-11194918 on NIH RePORTER |
What this research studies
This research focuses on developing a non-invasive imaging technique to visualize CD4 lymphocytes in the body of HIV-infected patients. By using advanced imaging technologies like PET and SPECT, the study aims to provide a detailed understanding of T-cell dynamics, including how HIV affects these cells and how they recover after treatment. This approach allows researchers to quantify CD4 receptor levels in lymphoid tissues, which is crucial for assessing immune health in patients undergoing antiretroviral therapy. The goal is to improve patient management and treatment strategies for those living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are HIV-infected and undergoing treatment.
Not a fit: Patients who are not infected with HIV or those who are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and treatment of HIV by providing insights into immune system recovery and T-cell dynamics.
How similar studies have performed: Previous studies have shown success in using similar imaging techniques in non-human primates, indicating potential for application in human patients.
Where this research is happening
Frederick, United States
- Leidos Biomedical Research, INC. — Frederick, United States (Active)
Researchers
- Principal investigator: Osborne, C.k. — Leidos Biomedical Research, INC.
- Study coordinator: Osborne, C.k.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.