Imaging CD4 cells in patients with HIV
Non-Invasive In Vivo Imaging of CD4 pool in HIV-1 Infected Patients
This study is looking at how HIV affects a type of immune cell called CD4 T-cells in people living with HIV, using special imaging techniques to see how these cells move and recover after treatment, which could help improve future treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Leidos Biomedical Research, INC. NIH-funded |
| Lab location | 1 site (Frederick, United States) |
| Project ID | NIH-10705883 on NIH RePORTER |
What this research studies
This research focuses on using advanced imaging techniques to visualize CD4 T-cells in the body of HIV-infected patients. By employing non-invasive methods like Positron Emission Tomography (PET), the study aims to provide insights into T-cell dynamics, including how HIV affects these immune cells and how they recover after treatment. The approach allows for a detailed understanding of immune reconstitution and T-cell trafficking, which is crucial for improving treatment strategies. Patients will undergo imaging to assess their CD4 cell levels and distribution in lymphoid tissues.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are HIV-infected and undergoing combination antiretroviral therapy.
Not a fit: Patients who are not infected with HIV or those who are not receiving treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and treatment strategies for HIV-infected patients, enhancing their immune recovery.
How similar studies have performed: Previous studies have shown success in using similar imaging techniques in non-human primates, indicating potential for application in human patients.
Where this research is happening
Frederick, United States
- Leidos Biomedical Research, INC. — Frederick, United States (Active)
Researchers
- Principal investigator: Osborne, C.k. — Leidos Biomedical Research, INC.
- Study coordinator: Osborne, C.k.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.