Imaging brain proteins linked to Alzheimer's disease
[18F]-PU-AD epichaperome PET imaging probe
This study is testing a new imaging tool that helps us see certain proteins in the brain linked to Alzheimer's disease, which could lead to better ways to diagnose and treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11297480 on NIH RePORTER |
What this research studies
This research focuses on developing a new imaging probe that can help visualize epichaperomes, which are protein structures involved in the progression of Alzheimer's disease and related cognitive disorders. By using positron emission tomography (PET), the study aims to provide insights into how these proteins affect brain function and contribute to cognitive decline. Patients may undergo imaging with the [124I]-PU-AD probe to assess the presence and impact of epichaperomes in their brains, potentially leading to better diagnostic and therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias who are undergoing cognitive decline.
Not a fit: Patients with cognitive disorders not related to Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools for Alzheimer's disease, enabling earlier detection and better-targeted treatments.
How similar studies have performed: Previous research has shown success in imaging similar protein structures in Alzheimer's disease, indicating a promising avenue for this novel approach.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Chiosis, Gabriela — Sloan-Kettering Inst Can Research
- Study coordinator: Chiosis, Gabriela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.