Imaging brain metabolism using a special glucose marker
HDO Imaging is a Quantitative Marker of Cerebral Glucose Oxidation
This study is looking at a new way to use imaging technology to see how cancer affects the way your brain uses sugar, which could help us understand brain health better, especially for people dealing with cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11129659 on NIH RePORTER |
What this research studies
This research investigates how a novel imaging technique can detect changes in brain metabolism, particularly in relation to cancer. By using deuterium magnetic resonance imaging (DMI) with a specific glucose marker, the study aims to improve the sensitivity of detecting glucose oxidation and glycolysis in the brain. The researchers will explore optimal dosing levels and the effects of insulin sensitivity on brain metabolism, utilizing advanced imaging methods to enhance spatial resolution. This approach could provide valuable insights into brain function and dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with brain cancer or other conditions affecting brain metabolism.
Not a fit: Patients with stable brain function and no metabolic disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools for detecting brain cancer and other metabolic disorders.
How similar studies have performed: Previous studies using deuterium magnetic resonance imaging have shown promise in identifying metabolic changes in the brain, suggesting this approach could be effective.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Merritt, Matthew E — University of Florida
- Study coordinator: Merritt, Matthew E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.