Imaging biomarkers for early detection of Lewy body dementia
Brainstem-based imaging biomarkers of premanifest synucleinopathy
This study is looking at new ways to spot early signs of Lewy body dementia by using special imaging techniques to see changes in the brain before symptoms show up, which could help people get the care they need sooner.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10867360 on NIH RePORTER |
What this research studies
This research focuses on developing advanced imaging techniques to identify early signs of Lewy body dementia, a common cause of cognitive decline. By targeting the brainstem, where neurodegeneration begins, the study aims to create biomarkers that can detect changes before symptoms appear. The approach involves using innovative imaging procedures to visualize tiny structures in the brain that are affected by the accumulation of alpha-synuclein protein. This early detection could lead to timely interventions that may slow disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are at risk for Lewy body dementia or exhibit early signs of cognitive decline.
Not a fit: Patients with established Lewy body dementia or those with other forms of dementia unrelated to Lewy bodies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enable earlier diagnosis and treatment of Lewy body dementia, potentially improving patient outcomes and quality of life.
How similar studies have performed: Previous research has shown promise in using imaging techniques for early detection of neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Bianciardi, Marta — Massachusetts General Hospital
- Study coordinator: Bianciardi, Marta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.