IGF-1 to protect newborn brains after intraventricular bleeding
IGF-1 and Innate Immunity in Neonatal Brain Injury
['FUNDING_R01'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-11194460
Looks at whether giving IGF-1 can help protect the developing brains of newborns who have had bleeding in the brain ventricles (IVH).
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-11194460 on ClinicalTrials.gov |
What this research studies
This project focuses on babies who suffer intraventricular hemorrhage (IVH), a brain bleed that can cause long-term motor and learning problems. Researchers will study how immune cells in the newborn brain (microglia) change after bleeding and how those cells' production of IGF-1 affects fragile myelin-forming cells (oligodendrocyte progenitor cells). In lab and preclinical experiments they will expose microglia to blood products, measure inflammatory signals and IGF-1 levels, and test whether giving extra IGF-1 helps OPC survival and myelination. The overall aim is to develop an approach that could be given after IVH to reduce white matter injury and improve long-term outcomes for affected infants.
Who could benefit from this research
Good fit: Ideal candidates would be newborns or premature infants diagnosed with intraventricular hemorrhage soon after birth.
Not a fit: This approach would likely not benefit older children or adults, or infants without bleeding in the brain.
Why it matters
Potential benefit: If successful, this work could lead to a therapy that protects white matter and reduces the risk of lifelong developmental disability after neonatal IVH.
How similar studies have performed: Preclinical studies support a protective role for IGF-1 in oligodendrocyte development, but using IGF-1 specifically for neonatal IVH is a newer and not yet well-tested strategy.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, BRANDON A — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: MILLER, BRANDON A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury