IDH mutations as drivers of organelle stress and dysfunction in cancer
Official title: Isocitrate dehydrogenase (IDH) mutations as drivers of organelle stress and dysfunction
Funded at San Diego State University · NIH-11348859 · Data updated 2026-11-12
A cancer-focused study explores how IDH1/IDH2 mutations create harmful byproducts and stress inside cells, which may drive tumor changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | August 1, 2020 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $395,448 |
| NIH project number | 5R35GM137773-07 |
| Project ID | NIH-11348859 on NIH RePORTER |
Who could benefit from this research
✓Could help
Candidates include patients with IDH-mutant cancers such as lower-grade gliomas, chondrosarcoma, or AML who may benefit from future targeted therapies.
✕Less likely to help
Patients with cancers not driven by IDH mutations or without access to future trials may not benefit.
What this research studies
This project investigates how mutations in IDH1 and IDH2 alter cellular metabolism and cause stress in organelles, contributing to cancers such as gliomas, chondrosarcomas, and AML. Researchers use structural analyses and biochemical approaches to identify which mutated residues drive the neomorphic activity and how it affects epigenetics and redox balance. The findings could point to new ways to target these cancer cells and improve treatments for patients with IDH-mutant tumors.
Why it matters
Potential benefit: If successful, the work could lead to better-targeted therapies for patients with IDH-mutant cancers and a clearer understanding of tumor biology.
How similar studies have gone: Previous work has established the role of IDH mutations and approved inhibitors; this project seeks to uncover deeper mechanistic insights that are still needed.
Where this research is happening
-
San Diego State University
San Diego, United States Active
Researchers
- Principal investigator: Sohl, Christal Dyane — San Diego State University
- Study coordinator: Sohl, Christal Dyane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.