Identifying triggers of stomach cell changes that may lead to cancer
Official title: Defining Inflammatory Triggers that Induce Diverse Subtypes of Gastric Metaplasia
Funded at Saint Louis University · NIH-10996195 · Data updated 2026-11-12
This study is looking at how long-term inflammation in the stomach, often caused by infections or autoimmune issues, can lead to changes in stomach cells that might increase the risk of cancer, and it aims to find out if these changes are different depending on what's causing the inflammation, which could help doctors create better treatments and monitoring for patients at risk of stomach cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $54,538 |
| NIH project number | 5F30DK134124-03 |
| Project ID | NIH-10996195 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with chronic gastritis, particularly those with Helicobacter pylori infection or autoimmune gastritis.
✕Less likely to help
Patients without chronic gastritis or those who do not have a history of gastric inflammation may not benefit from this research.
What this research studies
This research investigates how chronic inflammation in the stomach, caused by factors like Helicobacter pylori infection and autoimmune gastritis, leads to changes in stomach cells that can become pre-cancerous. By analyzing different molecular subtypes of gastric metaplasia, the research aims to understand whether these changes are similar or different depending on the cause of inflammation. This could help in developing targeted treatments and monitoring strategies for patients at risk of gastric cancer. The study employs advanced molecular techniques to characterize these cell changes and their implications for cancer development.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for gastric cancer, improving outcomes for patients at risk.
How similar studies have gone: Previous research has shown success in identifying molecular subtypes of gastric cancer, indicating that this approach may yield valuable insights into pre-cancerous conditions as well.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Hoft, Stella Garden — Saint Louis University
- Study coordinator: Hoft, Stella Garden
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.