Identifying the tissues and genes that cause different disease types
Fine-mapping causal tissues at disease-associated loci to infer disease subtypes
This study is looking at how certain genes and tissues are linked to complex diseases, helping us understand what causes different types of these diseases, which could lead to better treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11085181 on NIH RePORTER |
What this research studies
This research aims to uncover the specific tissues and genes responsible for various complex diseases by analyzing genetic data. It utilizes advanced statistical methods to accurately map disease-associated genetic loci to their causal tissues and genes. By examining gene expression across different tissues, the study seeks to identify how these factors contribute to disease subtypes. This approach could lead to a better understanding of disease mechanisms and improve patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with complex diseases that have a genetic component.
Not a fit: Patients with diseases that are not influenced by genetic factors or those without a clear genetic basis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment options based on the specific genetic and tissue-related factors influencing a patient's disease.
How similar studies have performed: Other research has shown promise in using genetic data to identify disease mechanisms, suggesting that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Strober, Benjamin — Harvard School of Public Health
- Study coordinator: Strober, Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.