Identifying the tissues and genes that cause different disease types
Official title: Fine-mapping causal tissues at disease-associated loci to infer disease subtypes
Funded at Harvard School of Public Health · NIH-11085181 · Data updated 2026-11-12
This study is looking at how certain genes and tissues are linked to complex diseases, helping us understand what causes different types of these diseases, which could lead to better treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $76,756 |
| NIH project number | 5F32HG012889-03 |
| Project ID | NIH-11085181 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with complex diseases that have a genetic component.
✕Less likely to help
Patients with diseases that are not influenced by genetic factors or those without a clear genetic basis may not benefit from this research.
What this research studies
This research aims to uncover the specific tissues and genes responsible for various complex diseases by analyzing genetic data. It utilizes advanced statistical methods to accurately map disease-associated genetic loci to their causal tissues and genes. By examining gene expression across different tissues, the study seeks to identify how these factors contribute to disease subtypes. This approach could lead to a better understanding of disease mechanisms and improve patient care.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment options based on the specific genetic and tissue-related factors influencing a patient's disease.
How similar studies have gone: Other research has shown promise in using genetic data to identify disease mechanisms, suggesting that this approach could yield significant insights.
Where this research is happening
-
Harvard School of Public Health
Boston, United States Active
Researchers
- Principal investigator: Strober, Benjamin — Harvard School of Public Health
- Study coordinator: Strober, Benjamin
Related research
Other NIH-funded projects on the same topics.
-
Using air purifiers to improve lung health in patients with eosinophilic COPD
This study is looking at whether using special air purifiers can help people with eosinophilic COPD breathe better and feel less discomfort, by comparing the effects of these purifiers to a fake device over a year.
-
Understanding how the immune system protects against tuberculosis
This study is looking at how our immune system fights tuberculosis and aims to find ways to improve vaccines, and people with tuberculosis can help by sharing samples or joining in on the research.
-
Understanding how the immune system protects against tuberculosis
This study is looking at how our immune system fights tuberculosis and aims to find ways to improve vaccines for it, especially for people who might also have other infections like HIV. If you're a patient, you might have the chance to help us understand your immune responses to support better vaccine development.
-
Improving software for family-based genetic testing
This study is working on improving a tool that helps families understand their genetic risks for diseases, so that patients and their loved ones can get better insights into their health based on the latest technology.
-
How different diets affect energy metabolism and body weight
This study is looking at how different amounts of fats and carbohydrates in your diet affect how your body uses energy, helping you understand how your food choices can influence your weight and metabolism.
-
Investigating the health effects of HIV treatments on children and young adults
This study is looking at how the antiretroviral medications taken by pregnant women with HIV affect their children as they grow up, so we can better understand their health needs as they become adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.