Identifying the source of seizures in patients with temporal lobe epilepsy using advanced imaging techniques
Seizure onset zone localization with functional MRI correlates of interictal physiology in temporal lobe epilepsy
This study is looking to help people with temporal lobe epilepsy who haven't found relief from medications by using special brain scans to better locate where their seizures start, which could lead to more successful surgery options.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11067741 on NIH RePORTER |
What this research studies
This research focuses on improving the localization of the seizure onset zone (SOZ) in patients with temporal lobe epilepsy who do not respond to medication. By utilizing advanced functional MRI techniques, the study aims to identify interictal physiological abnormalities that can help pinpoint the SOZ more accurately. Patients undergoing this research will participate in noninvasive imaging tests that measure brain activity, which may lead to better surgical outcomes. The goal is to enhance the precision of surgical interventions for those suffering from drug-resistant epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with temporal lobe epilepsy who have not responded to drug treatments and are being considered for surgical intervention.
Not a fit: Patients with epilepsy who are well-controlled on medication or those with other types of epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective surgical treatments for patients with epilepsy, potentially resulting in seizure freedom.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for seizure localization, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Sainburg, Lucas — Vanderbilt University
- Study coordinator: Sainburg, Lucas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.