Identifying the factors that influence the development of human motor neurons
Uncovering the transcription factors that control human motor neuron cell fate
This study is looking at how certain proteins help turn stem cells into motor neurons, which are important for movement, to better understand conditions like ALS and SMA, and to find new ways to create cells for research and treatment.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11070772 on NIH RePORTER |
What this research studies
This research investigates how specific transcription factors control the differentiation of pluripotent cells into motor neurons, which are crucial for muscle movement. By understanding the gene expression profiles regulated by these factors, the study aims to improve knowledge of developmental disorders and generate relevant cell types for disease modeling. The focus is on motor neurons affected by conditions like amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), which currently have limited treatment options. The research employs advanced techniques such as single-cell RNA sequencing to explore the transcription factor landscape during motor neuron development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or spinal muscular atrophy.
Not a fit: Patients with motor neuron diseases unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating ALS and SMA by enhancing the generation of healthy motor neurons.
How similar studies have performed: Other research has shown promise in understanding transcription factors in cell differentiation, indicating potential for success in this area.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Li, Siyi — New York University School of Medicine
- Study coordinator: Li, Siyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.