Identifying the best blood pressure treatments for older adults to improve cognitive health
Guiding next steps for SPRINT-MIND implementation: Identifying high-benefit subgroups and comparative effects of ARB- vs. ACEI-based regimens
This study is looking at how two types of blood pressure medications—ARBs and ACEIs—might help older adults not only manage their blood pressure but also support their brain health, to find out who might gain the most from these treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10614396 on NIH RePORTER |
What this research studies
This research investigates how different blood pressure medications, specifically angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs), affect cognitive health in older adults. It aims to determine which patients benefit the most from intensive blood pressure control and whether these medications have direct cognitive benefits beyond lowering blood pressure. By analyzing data from previous trials, the study seeks to provide insights that could lead to better treatment strategies for preventing cognitive decline in the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults with hypertension who are at risk for cognitive decline.
Not a fit: Patients who are not elderly or do not have hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that enhance cognitive health and reduce the risk of dementia in older adults.
How similar studies have performed: Previous studies have shown promising results regarding the cognitive benefits of ARBs compared to ACEIs, suggesting that this research builds on established findings.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Bress, Adam P — University of Utah
- Study coordinator: Bress, Adam P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.