Identifying targets to prevent ischemic strokes using protein and gene analysis
Proteomics and Genomics to Identify Therapeutic Targets for Ischemic Stroke Prevention
This study is looking for better ways to prevent strokes in people who have had a stroke before or have a heart condition called atrial fibrillation, by examining blood samples to find proteins that might increase stroke risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10941500 on NIH RePORTER |
What this research studies
This research investigates new methods to prevent ischemic strokes, particularly in individuals who have previously experienced a stroke or have atrial fibrillation. By analyzing blood samples and genetic data from a large cohort, the study aims to identify specific proteins that may contribute to stroke risk. The researchers will utilize advanced proteomic technologies to measure thousands of proteins and assess their relationship with future stroke occurrences over a long follow-up period. This approach seeks to uncover new therapeutic targets that could lead to more effective prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are survivors of a previous ischemic stroke or those diagnosed with atrial fibrillation.
Not a fit: Patients who have not experienced a stroke or do not have atrial fibrillation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that significantly reduce the risk of future strokes in high-risk populations.
How similar studies have performed: Previous research has shown promise in using proteomic and genomic approaches to identify risk factors for various diseases, suggesting potential for success in this novel application.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Kalani, Rizwan — University of Washington
- Study coordinator: Kalani, Rizwan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.