Identifying targets to prevent ischemic strokes using protein and gene analysis
Official title: Proteomics and Genomics to Identify Therapeutic Targets for Ischemic Stroke Prevention
Funded at University of Washington · NIH-10941500 · Data updated 2026-11-12
This study is looking for better ways to prevent strokes in people who have had a stroke before or have a heart condition called atrial fibrillation, by examining blood samples to find proteins that might increase stroke risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $624,583 |
| NIH project number | 1R01NS138297-01 |
| Project ID | NIH-10941500 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are survivors of a previous ischemic stroke or those diagnosed with atrial fibrillation.
✕Less likely to help
Patients who have not experienced a stroke or do not have atrial fibrillation may not benefit from this research.
What this research studies
This research investigates new methods to prevent ischemic strokes, particularly in individuals who have previously experienced a stroke or have atrial fibrillation. By analyzing blood samples and genetic data from a large cohort, the study aims to identify specific proteins that may contribute to stroke risk. The researchers will utilize advanced proteomic technologies to measure thousands of proteins and assess their relationship with future stroke occurrences over a long follow-up period. This approach seeks to uncover new therapeutic targets that could lead to more effective prevention strategies.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that significantly reduce the risk of future strokes in high-risk populations.
How similar studies have gone: Previous research has shown promise in using proteomic and genomic approaches to identify risk factors for various diseases, suggesting potential for success in this novel application.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Kalani, Rizwan — University of Washington
- Study coordinator: Kalani, Rizwan
Related research
Other NIH-funded projects on the same topics.
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Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
-
Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
-
Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
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Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.