Identifying targets for treating arrhythmogenic cardiomyopathy
Uncovering Molecular Targets for Arrhythmogenic Cardiomyopathy Therapeutics
This study is looking at a heart condition called ARVD/C that can be dangerous for young adults, and researchers are creating special mice to help them understand how the genetic changes affect the heart, with the hope of finding new treatments to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11075768 on NIH RePORTER |
What this research studies
This research focuses on understanding arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), a genetic heart disease that can lead to sudden death in young adults. The team is using advanced techniques like CRISPR-Cas9 to create a mouse model that mimics human mutations associated with this condition. By studying how these mutations affect heart cells and their connections, the researchers aim to uncover potential therapeutic strategies to restore normal function. This work could lead to new treatments that specifically address the underlying genetic causes of ARVD/C.
Who could benefit from this research
Good fit: Ideal candidates for this research are young adults diagnosed with arrhythmogenic cardiomyopathy or those with a family history of the condition.
Not a fit: Patients with arrhythmogenic cardiomyopathy caused by non-genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly improve outcomes for patients with arrhythmogenic cardiomyopathy.
How similar studies have performed: Previous research has shown promise in using genetic models to explore cardiac diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Sheikh, Farah — University of California, San Diego
- Study coordinator: Sheikh, Farah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.