Identifying targets for treating a specific type of heart arrhythmia.
Official title: Multiomics and Functional Characterization Establish Druggable Targets for PVC-Driven Idiopathic VF
Funded at University of Wisconsin-Madison · NIH-10873297 · Data updated 2026-11-12
This study is looking into a type of heart rhythm problem called Idiopathic Ventricular Fibrillation (IVF) to better understand how it works, and it's inviting patients with this condition to help by providing cells that can be studied in the lab, which could lead to better and more personalized treatments for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $749,641 |
| NIH project number | 5R01HL170521-02 |
| Project ID | NIH-10873297 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with idiopathic ventricular fibrillation, particularly those who do not fit existing diagnostic criteria.
✕Less likely to help
Patients with well-defined arrhythmia syndromes or those who do not have idiopathic ventricular fibrillation may not benefit from this research.
What this research studies
This research focuses on understanding a type of heart arrhythmia known as Idiopathic Ventricular Fibrillation (IVF), which affects many individuals without clear diagnostic criteria. By integrating advanced computational modeling and multiomic data, the study aims to uncover the underlying mechanisms of a specific subphenotype of IVF related to Purkinje-triggered ventricular fibrillation. Patients with this condition will be recruited to create induced pluripotent stem cells (iPSCs), allowing researchers to study heart cells in a lab setting. This approach could lead to more personalized and effective treatment options for those affected by this arrhythmia.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that significantly improve outcomes for patients with idiopathic ventricular fibrillation.
How similar studies have gone: While there has been significant research into arrhythmias, this specific approach integrating multiomics and computational modeling for IVF is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Eckhardt, Lee Lochbaum — University of Wisconsin-Madison
- Study coordinator: Eckhardt, Lee Lochbaum
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.