Identifying T cell receptor sequences that predict cancer outcomes
Official title: Special Public T Cell Receptor Sequences that Predict Outcomes for Cancer Patients
Funded at Northwestern University at Chicago · NIH-10757454 · Data updated 2026-11-12
This study is looking at certain T cell receptors in the blood of cancer patients to see if they can help predict how well patients will respond to treatments and how long they might live, especially for those with lung cancer and melanoma.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $177,650 |
| NIH project number | 5R21CA277285-02 |
| Project ID | NIH-10757454 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adult cancer patients, particularly those with lung cancer, renal cell carcinoma, or melanoma who are receiving immunotherapy.
✕Less likely to help
Patients with cancers not included in the study or those not undergoing immunotherapy may not benefit from this research.
What this research studies
This research investigates specific T cell receptor sequences, known as special public TCRs, that may indicate better outcomes for cancer patients. By analyzing blood samples from patients with various cancers, including lung cancer and melanoma, the study aims to determine how these TCRs correlate with patient survival and response to immunotherapy treatments. The researchers will utilize advanced techniques like single-cell sequencing to explore the characteristics of these TCRs and their potential role in enhancing cancer treatment effectiveness.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting which cancer patients will benefit most from immunotherapy.
How similar studies have gone: Previous research has shown promising results with similar approaches in identifying T cell receptor sequences linked to patient outcomes in cancer treatment.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Pollack, Seth M — Northwestern University at Chicago
- Study coordinator: Pollack, Seth M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.