Identifying specific weaknesses in lung cancer based on genetic profiles
Uncovering Oncogenotype-specific Vulnerabilities in Lung cancer
This study is looking at how certain genetic changes in lung cancer can affect how tumors use nutrients, with the hope of finding new treatment options that could help lung cancer patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11073123 on NIH RePORTER |
What this research studies
This research investigates how different genetic mutations in lung cancer affect tumor metabolism and identifies potential vulnerabilities that can be targeted for treatment. By analyzing lung cancer samples from patients with specific mutations, the study aims to understand how these genetic changes influence the way tumors metabolize nutrients. The goal is to find therapeutic strategies that exploit these metabolic differences, potentially leading to more effective treatments for lung cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer, particularly those with KRAS mutations or KRAS/LKB1 co-mutations.
Not a fit: Patients with lung cancer who do not have the specific genetic mutations being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies for lung cancer that are tailored to the specific genetic makeup of a patient's tumor.
How similar studies have performed: Other research has shown promise in targeting metabolic vulnerabilities in cancer, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Kim, Jiyeon — Yale University
- Study coordinator: Kim, Jiyeon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.