Identifying specific vascular cell types related to various diseases
Identifying the organotypic and disease-specific vascular cell populations by integrating single cell data with polygenic risk
This study is looking at how different types of blood vessel cells might be linked to diseases like heart problems, strokes, dementia, and cancer, so that we can better understand how keeping your blood vessels healthy could help improve your overall health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11179608 on NIH RePORTER |
What this research studies
This research investigates the role of vascular cells in various diseases by using advanced single cell analysis techniques. It aims to identify distinct populations of endothelial cells and vascular smooth muscle cells that may contribute to conditions such as coronary artery disease, stroke, dementia, and cancer. By integrating data from the Human BioMolecular Atlas Program, the research seeks to establish causal links between specific vascular cell types and disease risk, potentially leading to new insights into vascular dysfunction. Patients may benefit from a better understanding of how vascular health impacts their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for arterial diseases, dementia, cancer, or diabetes.
Not a fit: Patients with conditions unrelated to vascular health or those who do not have risk factors for the diseases studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for diseases linked to vascular dysfunction.
How similar studies have performed: Other research has shown success in using single cell analysis to identify vascular cell populations, indicating that this approach is promising and has been validated in related studies.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Gupta, Rajat M — Brigham and Women's Hospital
- Study coordinator: Gupta, Rajat M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.