Identifying specific vascular cell populations linked to diseases
Identifying the organotypic and disease-specific vascular cell populations by integrating single cell data with polygenic risk
This study is looking at how different types of blood vessel cells in our bodies might play a role in diseases like heart problems, strokes, dementia, and cancer, with the hope of finding new ways to understand and treat these conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10847519 on NIH RePORTER |
What this research studies
This research investigates how different types of vascular cells in the body contribute to various diseases, including heart disease, stroke, dementia, and cancer. By using advanced techniques like single cell RNA sequencing, the researchers aim to uncover the specific roles of these cells in disease processes. The study will analyze data from the Human BioMolecular Atlas Program to establish connections between vascular cell types and disease risk, potentially leading to new insights into vascular dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for arterial diseases, dementia, cancer, or diabetes.
Not a fit: Patients with no history of vascular disease or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of diseases linked to vascular dysfunction.
How similar studies have performed: Other research has shown promise in identifying vascular cell populations and their roles in disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Gupta, Rajat M — Brigham and Women's Hospital
- Study coordinator: Gupta, Rajat M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.