Identifying specific T cells that fight lung cancer
Official title: Unbiased electrothermal flow-enhanced identification of antigen-specific T cells in lung cancer
Funded at University of Tx Md Anderson Can Ctr · NIH-10723218 · Data updated 2026-11-12
This study is looking to make lung cancer treatments better by finding out which specific T cells can effectively target the cancer, so that patients can receive more personalized and effective immunotherapy options.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $412,768 |
| NIH project number | 1R21CA283852-01 |
| Project ID | NIH-10723218 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with lung cancer who are seeking innovative treatment options.
✕Less likely to help
Patients with lung cancer who are not eligible for immunotherapy or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research focuses on improving immunotherapy for lung cancer by developing a method to identify T cells that specifically target tumor antigens. Current therapies often activate a wide range of T cells without knowing their specific targets, which can lead to ineffective treatments. The researchers aim to create unbiased techniques to better understand which T cells are effective against lung cancer, potentially leading to more personalized and effective immunotherapy options for patients. By analyzing tumor antigens and the T cells that recognize them, this study seeks to enhance the precision of cancer treatments.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies that specifically target lung cancer, improving patient outcomes.
How similar studies have gone: Other research has shown promise in identifying specific T cell responses in cancer, but this approach aims to address significant gaps in current methodologies.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Reuben, Alexandre — University of Tx Md Anderson Can Ctr
- Study coordinator: Reuben, Alexandre
Related research
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Integrative Analysis of Lung Cancer Risk and Causes
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Proteomics-guided matching of lung cancer tumors to preclinical models
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Optimizing lung cancer care with smart tools for prevention, early detection, treatment, and survivorship
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.