Identifying specific immune cells involved in Multiple Sclerosis
Detection of disease-relevant CD8+ T cells in Multiple Sclerosis
This study is looking at how certain immune cells called CD8+ T cells behave in people with Multiple Sclerosis compared to those who are healthy, to better understand their role in the disease.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10641813 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of CD8+ T cells in Multiple Sclerosis (MS), a condition where the immune system attacks the central nervous system. The study aims to identify specific CD8+ T cell epitopes that may be more prevalent in MS patients compared to healthy individuals. Additionally, it will analyze the diversity of CD8+ T cells in the blood and cerebrospinal fluid of MS patients using advanced sequencing techniques. By doing so, the research seeks to uncover the mechanisms by which these immune cells contribute to the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Multiple Sclerosis.
Not a fit: Patients with other neurological disorders or those without a diagnosis of Multiple Sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the immune mechanisms of Multiple Sclerosis, potentially guiding more effective treatments.
How similar studies have performed: While the role of CD8+ T cells in MS is not fully understood, there is emerging evidence suggesting their involvement, making this research both relevant and potentially groundbreaking.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Sabatino, Joseph John — University of California, San Francisco
- Study coordinator: Sabatino, Joseph John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.