Identifying skin biomarkers for Alzheimer's disease and related dementias
Skin biomarkers for diagnosing and characterizing AD and ADRD
This study is working on a new way to detect signs of Alzheimer's disease and similar conditions by testing skin samples, which could help doctors diagnose these diseases earlier and more accurately.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10892803 on NIH RePORTER |
What this research studies
This research focuses on developing sensitive tests to detect misfolded proteins associated with Alzheimer's disease (AD) and related dementias (ADRD) using skin samples. By employing advanced techniques like real-time quaking-induced conversion (RT-QuIC) and protein misfolding cyclic amplification (PMCA), the study aims to create reliable assays that can diagnose these conditions earlier and more accurately than current methods. This approach could help in assessing disease severity and evaluating treatment effectiveness in clinical settings.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals showing early signs of Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of Alzheimer's disease and related dementias, improving patient outcomes.
How similar studies have performed: Previous research has successfully used similar techniques to detect misfolded proteins in other neurodegenerative diseases, indicating potential for success in this area.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Kraus, Allison L — Case Western Reserve University
- Study coordinator: Kraus, Allison L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.