Identifying signs of increased pressure in children's brains using CT scans
Official title: Development of CT image-based cranial bone markers of intra-cranial hypertension
Funded at University of Colorado Denver · NIH-10892783 · Data updated 2026-11-12
This study is looking for a safe and easy way to spot high pressure inside the skull in kids aged 0 to 11 by examining their CT scans, which could help doctors catch this condition more reliably without needing to do any invasive tests.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $237,131 |
| NIH project number | 5R21DE031824-02 |
| Project ID | NIH-10892783 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0 to 11 years who may be experiencing symptoms related to increased intracranial pressure.
✕Less likely to help
Patients outside the age range of 0 to 11 years or those without symptoms of intracranial hypertension may not benefit from this research.
What this research studies
This research aims to develop a non-invasive method to detect intracranial hypertension (ICH) in pediatric patients by analyzing CT images of the head. The study focuses on understanding how elevated intracranial pressure affects the density and thickness of cranial bones in children aged 0 to 11 years. By creating a statistical model based on a large set of CT images, the researchers hope to provide a more accurate and reliable way to identify ICH, which is often underdiagnosed. This approach could help avoid the risks associated with invasive monitoring methods.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnosis of intracranial hypertension in children, potentially preventing serious complications.
How similar studies have gone: Previous research has shown promise in using imaging techniques to assess cranial bone characteristics, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Porras Perez, Antonio Reyes — University of Colorado Denver
- Study coordinator: Porras Perez, Antonio Reyes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.