Identifying RNA structures that affect human health and disease
Discovery of structural RNAs involved in human health and disease
This study is looking at special RNA structures that are important for how our cells work, and it aims to find new ones that could be connected to health issues, which might help in developing new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10904917 on NIH RePORTER |
What this research studies
This research focuses on discovering and understanding various RNA structures that play crucial roles in cellular functions and are conserved through evolution. By utilizing advanced statistical methods and algorithms, the researchers aim to predict RNA structures and identify new conserved RNAs that may be linked to health and disease. The study employs innovative techniques like R-scape and CaCoFold to analyze RNA covariation and folding, which could lead to significant insights into non-coding RNAs relevant to human health. Patients may benefit from the findings as they could reveal new targets for therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions linked to RNA dysfunction or those interested in genetic research.
Not a fit: Patients with conditions unrelated to RNA structures or those not involved in genetic research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into RNA-related mechanisms of disease, potentially guiding the development of novel treatments.
How similar studies have performed: Other research has shown success in identifying RNA structures and their roles in disease, suggesting that this approach has potential for meaningful discoveries.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Rivas, Elena — Harvard University
- Study coordinator: Rivas, Elena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.