Identifying RNA sequences and proteins that control circular RNA translation
Official title: Systematic identification of RNA sequences and protein components regulating circular RNA translation
Funded at Washington University · NIH-10925379 · Data updated 2026-11-12
This study is looking at how certain RNA sequences and proteins help control the production of circular RNAs, which play important roles in cell growth and movement, and it aims to find out how problems in this process might be linked to cancer, with the hope of discovering new treatments that could help patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 8, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $245,945 |
| NIH project number | 5R00HG011475-04 |
| Project ID | NIH-10925379 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers where circRNA translation may play a role in tumorigenesis.
✕Less likely to help
Patients with conditions unrelated to circRNA translation or those not diagnosed with cancer may not benefit from this research.
What this research studies
This research focuses on understanding how certain RNA sequences and proteins regulate the translation of circular RNAs, which are crucial for various biological functions like cell growth and movement. By developing a high-throughput screening technology, the researchers aim to distinguish between circular and linear RNAs and identify the specific components that drive their translation. This could lead to insights into how disruptions in these processes may contribute to cancer development and progression. Patients may benefit from advancements in understanding these mechanisms, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer mechanisms and the development of targeted therapies.
How similar studies have gone: While the approach is innovative, similar research has shown promise in understanding RNA regulation, indicating potential for success.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Chen, Chun-Kan — Washington University
- Study coordinator: Chen, Chun-Kan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.