Identifying RNA biomarkers for osteoarthritis progression
Official title: Extracellular RNA Expression Biomarkers in Osteoarthritis Disease and Progression
Funded at University of Miami School of Medicine · NIH-10793650 · Data updated 2026-11-12
This study is looking at how certain markers in the blood can help us understand osteoarthritis better, especially for older adults, so we can find more personalized and effective treatments for the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | February 22, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $163,785 |
| NIH project number | 5R21AR080270-02 |
| Project ID | NIH-10793650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with knee osteoarthritis or those at risk for developing the disease.
✕Less likely to help
Patients with osteoarthritis who do not have a confirmed diagnosis or those with other unrelated joint conditions may not benefit from this research.
What this research studies
This research focuses on understanding osteoarthritis (OA), a degenerative joint disease that affects many individuals, particularly the aging population. The study aims to identify specific RNA biomarkers in the blood that correlate with different clinical manifestations of OA. By analyzing data from a large cohort of nearly 5000 participants, the researchers will cluster individuals based on their symptoms and disease progression, using advanced RNA sequencing techniques to uncover potential biomarkers. This could lead to more targeted and effective treatments for OA.
Why it matters
Potential benefit: If successful, this research could lead to the development of personalized treatments for osteoarthritis based on individual biomarker profiles.
How similar studies have gone: Previous research has shown promise in using RNA biomarkers for other complex diseases, suggesting potential success for this approach in osteoarthritis.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Griswold, Anthony John — University of Miami School of Medicine
- Study coordinator: Griswold, Anthony John
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.