Identifying risks for sepsis in severely burned patients
Official title: Identification of sub-phenotypes of severely ill burn patients and risk for secondary sepsis: SEPSISBURN
Funded at University of California, San Francisco · NIH-10927455 · Data updated 2026-11-12
This study is looking at how serious burn injuries can increase the chances of getting a dangerous infection called sepsis, and it's for burn patients to help find ways to spot those at higher risk early on so they can get better care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 15, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $454,313 |
| NIH project number | 5R01GM151494-02 |
| Project ID | NIH-10927455 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have sustained severe burn injuries.
✕Less likely to help
Patients with minor burns or those who are not experiencing severe inflammatory responses may not benefit from this research.
What this research studies
This research focuses on understanding how severe burn injuries can lead to a heightened risk of sepsis, a serious infection that can be life-threatening. The team aims to identify specific biological markers that can help detect which burn patients are at greater risk for developing sepsis early on. By analyzing the body's inflammatory response and cardiovascular changes following a burn injury, the researchers hope to develop better diagnostic tools for early intervention. This could significantly improve patient outcomes in burn care settings.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and treatment of sepsis in burn patients, potentially reducing mortality rates.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for sepsis in other patient populations, but this approach is novel for the specific context of burn injuries.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Legrand, Matthieu — University of California, San Francisco
- Study coordinator: Legrand, Matthieu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.