Identifying risk factors for worsening symptoms in COPD using CT scans
Official title: Risk Stratification for COPD Exacerbations with CT Analysis and Multidimensional Trajectory Subtyping
Funded at Brigham and Women's Hospital · NIH-11052471 · Data updated 2026-11-12
This study is looking to help people with chronic obstructive pulmonary disease (COPD) by figuring out which patients might have more serious flare-ups of their symptoms, using special imaging and health information to create tailored treatment plans that could improve their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $819,313 |
| NIH project number | 5R01HL164380-03 |
| Project ID | NIH-11052471 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic obstructive pulmonary disease (COPD) who are experiencing varying degrees of symptoms.
✕Less likely to help
Patients with mild or no symptoms of COPD may not benefit from this research as they are less likely to experience exacerbations.
What this research studies
This research aims to better understand chronic obstructive pulmonary disease (COPD) by identifying which patients are at higher risk for severe symptom flare-ups, known as exacerbations. Using advanced CT imaging techniques, the study will analyze various biomarkers related to lung and heart health, as well as patient history, to categorize individuals into distinct risk groups. By employing a sophisticated algorithm that tracks changes over time, the research seeks to pinpoint early indicators of worsening health in COPD patients. This approach could lead to more personalized treatment plans and improved management of the disease.
Why it matters
Potential benefit: If successful, this research could lead to earlier identification of patients at risk for severe COPD exacerbations, allowing for timely interventions and better management of their condition.
How similar studies have gone: Previous research has shown promise in using imaging techniques and biomarker analysis to improve understanding of COPD, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Ross, James — Brigham and Women's Hospital
- Study coordinator: Ross, James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.