Identifying risk factors for type 2 diabetes in adolescents
Official title: Identify risk factors for type 2 diabetes in adolescents
Funded at Research Inst Nationwide Children's Hosp · NIH-11053343 · Data updated 2026-11-12
This study is looking at what causes type 2 diabetes in kids aged 9 to 13, especially those who are overweight, to help figure out who might be at risk and how to prevent it.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | April 19, 2023 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $684,083 |
| NIH project number | 5U01DK135015-03 |
| Project ID | NIH-11053343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents aged 9-13 years who are classified as obese and have impaired fasting glucose or impaired glucose tolerance.
✕Less likely to help
Patients who are not adolescents or do not have obesity or glucose intolerance may not benefit from this research.
What this research studies
This research investigates the risk factors that contribute to the development of type 2 diabetes (T2D) in adolescents, particularly focusing on those who are obese. The study will involve a cohort of 3,500 youth aged 9-13 years, assessing their insulin sensitivity, glucose levels, and other biological markers. By understanding the mechanisms behind T2D in this age group, the research aims to identify which adolescents are at higher risk and how to prevent the onset of this condition. Participants will be recruited from diverse urban and rural settings in Ohio, ensuring a comprehensive understanding of the factors involved.
Why it matters
Potential benefit: If successful, this research could lead to better identification and prevention strategies for type 2 diabetes in adolescents, ultimately improving their long-term health outcomes.
How similar studies have gone: Previous research has shown success in identifying risk factors for diabetes in adults, but this specific focus on adolescents is relatively novel.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Hoffman, Robert Paul — Research Inst Nationwide Children's Hosp
- Study coordinator: Hoffman, Robert Paul
Related research
Other NIH-funded projects on the same topics.
-
Why some teens develop type 2 diabetes
This project looks at how puberty, obesity, and social or behavioral factors may cause some adolescents to develop type 2 diabetes.
-
Using a very low-carbohydrate diet to lower diabetes risk
This study is looking at whether a very low-carb diet can help people at risk for type 2 diabetes do better in a program designed to prevent the disease, and it’s for adults who want to improve their blood sugar levels and overall health.
-
Investigating the impact of PFAS on kidney disease in young people with type 2 diabetes
This study is looking at how certain chemicals called PFAS might affect kidney health in young people with type 2 diabetes, helping to find out who might be at risk for kidney problems and how these chemicals could be involved.
-
Investigating the impact of fat around the heart on diabetes and heart health in young people undergoing weight loss surgery
This study is looking at how the fat around the heart affects heart health in teenagers with type 2 diabetes who are having weight loss surgery, using special heart scans to find out more about it and see how different diabetes treatments might help.
-
Investigating how sugary and artificially sweetened beverages affect diabetes risk factors
This study is looking at how drinking sugary and artificially sweetened drinks might affect your risk of developing type 2 diabetes, and it aims to help people understand how their beverage choices can impact their health.
-
Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.