Identifying risk factors for sudden unexpected death in epilepsy (SUDEP)
Official title: Biomarkers of SUDEP risk based on brain-heart-lungs network dynamics
Funded at Southern Methodist University · NIH-11005002 · Data updated 2026-11-12
This study is looking for signs that could help predict the risk of sudden unexpected death in people with epilepsy by examining how the brain, heart, and lungs work together during seizures, using specially modified mice to learn more about these connections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Methodist University NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | January 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $560,583 |
| NIH project number | 5R01NS129643-03 |
| Project ID | NIH-11005002 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with epilepsy who may be at risk for SUDEP.
✕Less likely to help
Patients without epilepsy or those who do not experience seizures are unlikely to benefit from this research.
What this research studies
This research aims to discover biomarkers that indicate the risk of sudden unexpected death in epilepsy (SUDEP) by studying the interactions between the brain, heart, and lungs. Using advanced bioengineering techniques, the researchers will analyze how these organ systems communicate during seizures and as the risk of SUDEP increases. The study will involve animal models, specifically genetically modified mice, to observe changes in physiological dynamics over time. By understanding these pathways, the goal is to develop reliable methods for predicting SUDEP risk in patients with epilepsy.
Why it matters
Potential benefit: If successful, this research could lead to the development of predictive tools that help identify individuals at high risk for SUDEP, potentially saving lives.
How similar studies have gone: While the approach of using inter-organ connectivity analysis is innovative, previous research has shown promise in identifying biomarkers for other conditions, suggesting potential for success in this area as well.
Where this research is happening
-
Southern Methodist University
Dallas, United States Active
Researchers
- Principal investigator: Glasscock, Albert E — Southern Methodist University
- Study coordinator: Glasscock, Albert E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.