Identifying resistance to cancer immunotherapy using advanced imaging techniques
Official title: Early identification of immunotherapy resistance through integrated multiparameter imaging
Funded at University of California, San Francisco · NIH-11050284 · Data updated 2026-11-12
This study is looking at new ways to see if cancer patients are not responding to their immunotherapy treatments, so doctors can adjust their care to keep them safe and healthy while getting the best results.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $676,006 |
| NIH project number | 1R01CA290027-01A1 |
| Project ID | NIH-11050284 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients currently undergoing immunotherapy, particularly those receiving immune checkpoint inhibitors.
✕Less likely to help
Patients who are not receiving immunotherapy or those with cancers not targeted by immune checkpoint inhibitors may not benefit from this research.
What this research studies
This research focuses on developing non-invasive imaging methods to detect when cancer patients are not responding to immunotherapy treatments. By understanding the mechanisms behind resistance, the study aims to help doctors keep patients on effective therapies while avoiding harmful side effects from other treatments. The approach involves monitoring specific immune responses and tumor characteristics to tailor treatment strategies for better outcomes. Patients who are receiving immune checkpoint inhibitors for cancer will be the primary focus of this investigation.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for cancer patients, allowing for better management of immunotherapy and enhanced patient outcomes.
How similar studies have gone: Other research has shown promise in using imaging techniques to monitor treatment responses in cancer, suggesting that this approach could be effective.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Anwar, Mekhail — University of California, San Francisco
- Study coordinator: Anwar, Mekhail
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.